Studies of CBD's effects on anxiety and depression

             1) CBD has a rapid and long-lasting antidepressant effect:

The results of this study demonstrate that CBD exerts “fast and maintained antidepressant-like effects. (...) This work evidences that CBD could represent a novel drug for treating depressive disorders in a very fast manner, acting via the enhancement of serotonergic and glutamatergic transmission through the modulation of 5-HT1A receptors.”

* Study based on an animal model.


            2) CBD reduces anxiety disorders:

                        2.1 CBD has positive effects on many anxiety disorders: generalized anxiety disorder, panic disorder, social anxiety disorder, obsessive-compulsive disorder and post-traumatic stress disorder

This study, which reviews several previous studies, points out that it is “existing preclinical evidence strongly supports CBD as a treatment for generalized anxiety disorder, panic disorder, social anxiety disorder, obsessive–compulsive disorder, and post-traumatic stress disorder when administered acutely. [...] Likewise, evidence from human studies supports an anxiolytic role of CBD, but is currently limited to acute dosing, also with few studies in clinical populations. Overall, current evidence indicates CBD has considerable potential as a treatment for multiple anxiety disorders, with need for further study of chronic and therapeutic effects in relevant clinical populations.”

* Grouping of studies.

This second article, based on a set of studies, also emphasizes that “Studies using animal models of anxiety and involving healthy volunteers clearly suggest an anxiolytic-like effect of CBD. Moreover, CBD was shown to reduce anxiety in patients with social anxiety disorder.”

* Grouping of studies based on the study of healthy volunteers and animal models.


                        2.2 Decrease in social anxiety after a single dose of CBD


This study highlights a decrease in social anxiety by providing a single dose of CBD in the face of one of the main Social Anxiety Syndrome’s phobic stimuli : speaking in public. “CBD has had rapid and very interesting therapeutic effects in the patients concerned.” “Pretreatment of SAD (Social Anxiety Syndrome) patients with CBD significantly reduced anxiety, cognitive impairment, and discomfort in their speech performance (S) and significantly decreased alert in their anticipatory speech (A). The cognitive impairment, discomfort, and alert of SAD patients that received CBD had similar results to the Healthy Control patients (HC) during the speaking public simulation (SPST). These preliminary results indicate that a single dose of CBD can reduce the anxiety-enhancing effect provoked by SPST in SAD patients, indicating that this cannabinoid inhibits the fear of speaking in public, one of the main symptoms of the disorder”

* Study based on the study of SAD patients and healthy control patients.


                        2.3 CBD would be effective in combating anxiety attacks and panic attacks


We quote directly the article: “The studies assessed clearly suggest an anxiolytic-like effect of CBD in both animal models and healthy volunteers. CBD seems to be a promising drug for the treatment of Panic Disorder (PD). However, novel clinical trials involving patients with the PD diagnosis, however, are clearly needed to clarify the specific mechanism of action of CBD and the safe and ideal therapeutic doses of this compound. (…) Moreover, because this compound does not induce dependence, tolerance and abstinence symptoms, it can be, in the future, a good alternative as a substitute for high potency benzodiazepines and antidepressant drugs in PD patients who are resistant to the current treatments.”

* Grouping of studies based on the study of animal models and healthy volunteers.